This review traces the evolution of clustered regularly interspaced short palindromic repeats (CRISPR) technology from a prokaryotic immune mechanism to a versatile tool for precise genome engineering.
In addition to its broad application in genome engineering and therapeutics, clustered regularly interspaced short palindromic repeats (CRISPR) technology provides field-deployable methods for the highly sensitive and selective detection of nucleic acids.
Resistance to antibiotics, anticancer, antiviral, and antiparasitic drugs has become one of the greatest threats to modern medicine, seriously straining global health systems.
T cells can be reprogrammed with transgenic antigen recognition receptors, including chimeric antigen receptors and T cell receptors, to selectively recognize and kill cancer cells.
Un nuovo riconoscimento internazionale per la ricerca dell’IRCCS San Raffaele: è stato pubblicato sulla prestigiosa rivista Advanced Drug Delivery Reviews l’articolo intitolato "CRISPR/Cas bioimaging: from whole body biodistribution to single cell dynamics", a firma di un team multidisciplinare che vede tra i protagonisti il Prof. Ennio Tasciotti, Responsabile dell’area di ricerca pre-clinica di Human Longevity Program dell’Istituto romano.
This EMBO workshop will bring together experts in the editing space, who are studying the CRISPR-Cas immune defence system, developing novel and safer editing approaches, and applying them to the clinic.
I progressi nella tecnologia di editing genetico nota come Crispr-Cas9 negli ultimi 15 anni hanno fornito nuove importanti informazioni sui ruoli che specifici geni svolgono in molte malattie.
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